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Nrf2 activator-4

CAS No. 2383016-68-8

Nrf2 activator-4( —— )

Catalog No. M35687 CAS No. 2383016-68-8

Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Nrf2 activator-4
  • Note
    Research use only, not for human use.
  • Brief Description
    Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.
  • Description
    Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Reactive Oxygen Species | Nrf2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2383016-68-8
  • Formula Weight
    468.9
  • Molecular Formula
    C23H24ClF3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (213.27 mM; Ultrasonic )
  • SMILES
    Cl.CN1CCN(CC1)C(=O)COc1ccc(cc1)C(=O)\C=C\c1ccccc1C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777. ?
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